N-Boc-1-oxa-6-azaspiro[2.5]octane

N-Boc-1-oxa-6-azaspiro[2.5]octane - Names and Identifiers

Name	N-Boc-1-oxa-6-azaspiro[2.5]octane
Synonyms	N-Boc-1-oxa-6-azaspiro[2.5]octane 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID N-Boc-1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid 6-Aza-1-oxaspiro[2.5]octane-6-carboxylic acid tert-butyl ester 1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester 1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER tert-Butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate, 6-(tert-Butoxycarbonyl)-1-oxa-6-azaspiro[2.5]octane
CAS	147804-30-6
EINECS	687-899-9
InChIKey	ULSBMKGFFFMGOI-UHFFFAOYSA-N

N-Boc-1-oxa-6-azaspiro[2.5]octane - Physico-chemical Properties

Molecular Formula	C11H19NO3
Molar Mass	213.27
Density	1.12
Melting Point	50-52℃
Boling Point	297.6±33.0 °C(Predicted)
Appearance	Shape Crystalline Powder, color White
Color	White
pKa	-0.82±0.20(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Use	Application 1-oxa-6-aza-spirol [2.5] oct-6-formate tert-butyl ester is an organic intermediate, which can be prepared by the reaction of N-Boc-4-piperidone and trimethylsulfoxide iodide.

N-Boc-1-oxa-6-azaspiro[2.5]octane - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
HS Code	29349990
Hazard Class	IRRITANT

N-Boc-1-oxa-6-azaspiro[2.5]octane - Upstream Downstream Industry

Downstream Products

4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

N-Boc-1-oxa-6-azaspiro[2.5]octane - Preparation

dissolve trimethyl iodide sulfoxide (3.094g,14.06mmol,1.4eqv) in 15mL of anhydrous DMSO, add sodium hydride (0.562g,14.06mmol,1.4eqv,60% in kerosene) in three batches under the condition of ice bath, add it, stir at 0 ℃ for 30 minutes, add N-Boc-4-piperidone (2.0g,10.04mmol,1.0eqv), after adding, continue stirring at this temperature for 4 hours; Add 40mL of water, extract ethyl acetate (3 × 90mL), wash saturated salt water, dry anhydrous sodium sulfate, filter, concentrate to obtain crude product, column chromatography (PE:EA = 10:1, then PE:EA = 5:1) Compound 1-oxa-6-aza-spiro [2.5] oct-6-formate tert-butyl ester (1.285g, white waxy solid, 60% yield) was obtained.

Last Update：2024-04-10 22:29:15

N-Boc-1-oxa-6-azaspiro[2.5]octane - Reference Information

Application

1-oxa-6-aza-spiro [2.5] oct-6-carboxylic acid tert-butyl ester is an organic intermediate, it can be prepared by reacting N-Boc-4-piperidone with trimethyl sulfoxide iodide.

preparation

trimethylsulfoxide iodide (3.094g,14.06mmol,1.4eqv) was dissolved in 15ml of anhydrous DMSO, under the condition of ice bath, sodium hydride (0.562g,14.06mmol,1.4eqv,60% in kerosene) was added in three portions, and the mixture was stirred at 0 ° C. For 30 minutes, n-Boc-4-piperidone (2.0g,10.04mmol,1.0eqv) was added and stirring was continued at this temperature for 4 hours; Water (40ml) was added and the mixture was extracted with ethyl acetate (3 × 90ml), saturated brine washing, anhydrous sodium sulfate drying, filtration, concentration to obtain crude, column chromatography (PE:EA = 10:1, then PE:EA = 5:1) the compound 1-oxa-6-aza-spiro [2.5] oct-6-carboxylic acid tert-butyl ester (1.285g, white waxy solid, yield 60%) was obtained.

Last Update：2024-04-09 20:45:29